Akkermansia 500 Pro

Akkermansia muciniphila has appeared in over 3,000 scientific publications, and abundance has been associated with maintaining intestinal integrity. The primary function of Akkermansia muciniphila is to support healthy mucin layer turnover in the intestines, and thus strengthen the intestinal lining.

Furthermore, Akkermansia muciniphila releases short chain fatty acids such as acetate and propionate, that support the abundance and diversity of other health-promoting microorganisms in the gut.

1.Higher levels of Akkermansia have been associated with longevity and individuals fighting autoimmune diseases. Higher levels observed in stool may be due to a change in the gut lining, releasing Akkermansia into the fecal bolus. The current leading hypothesis on mechanism of action from researchers is that the body upregulates biological pathways and/or substances that help protect it when health is negatively impacted.

2. During infection, inflammatory markers increase because the inflammatory pathways are turned on to battle infection. More inflammatory proteins in the context of infection are a good sign. The way our microbiome is linked to our immune system is still being elucidated but there are preliminary studies showing the microbiome can respond to the host's immune and inflammatory pathways. There is a lot of ongoing research aimed at elucidating these complex relationships.

References (1) Geerlings SY, Kostopoulos I, De Vos WM, Belzer C. Akkermansia muciniphila in the Human Gastrointestinal Tract: When, Where, and How? Microorganisms. 2018;6(3):75. doi:10.3390/microorganisms6030075

(2) Cox LM, Maghzi AH, Liu S, Tankou SK, Dhang FH, Willocq V, Song A, Wasén C, Tauhid S, Chu R, Anderson MC, De Jager PL, Polgar-Turcsanyi M, Healy BC, Glanz BI, Bakshi R, Chitnis T, Weiner HL. Gut Microbiome in Progressive Multiple Sclerosis. Ann Neurol. 2021 Jun;89(6):1195-1211. doi: 10.1002/ana.26084. Epub 2021 Apr 30. PMID: 33876477; PMCID: PMC8132291. 

(3) Anhê FF, Pilon G, Roy D, Desjardins Y, Levy E, Marette A. TriggeringAkkermansiawith dietary polyphenols: A new weapon to combat the metabolic syndrome? Gut Microbes. 2016;7(2):146-153. doi:10.1080/19490976.2016.1142036

 (4) Bhullar, Khushwant S, and H P Vasantha Rupasinghe. “Polyphenols: multipotent therapeutic agents in neurodegenerative diseases.” Oxidative medicine and cellular longevity vol. 2013 (2013): 891748. doi:10.1155/2013/891748

(5) Zhou K. Strategies to promote abundance of Akkermansia muciniphila, an emerging probiotics in the gut, evidence from dietary intervention studies. Journal of Functional Foods. 2017;33:194-201. doi:10.1016/j.jff.2017.03.045(5) Zhou K. Strategies to promote abundance of Akkermansia muciniphila, an emerging probiotics in the gut, evidence from dietary intervention studies. Journal of Functional Foods. 2017;33:194-201. doi:10.1016/j.jff.2017.03.045